| Acronym | Meaning |
| UNMOVIC | United Nations Monitoring |
| UNOSOM | United Nations Operations In Somalia |
| UNPROFOR | United Nations Protection Force (in Former Yugoslavia) |
| UNRISD | United Nations Research Institute For Social Development |
| UNSM | Union Of Nova Scotian Municipalities |
| UNTAC | United Nations Transitional Authority In Cambodia |
| UNTAET | United Nations Transitional Administration In East Timor |
| UNU | United Nations University |
| UO | Urban Operations |
| UOG | University Of Guelph |
| UP | Ukraine (FIPS 10-4 Country Code) -Uttar Pradesh |
| UPC | Universal Product Code |
| UPDM | Uganda People?s Democratic Movement - Unified Modeling Language Profile For DoDAF And MoDAF - Unit? De Psychiatrie Du D?veloppement Mental - Universal Pattern Decomposition Method - Unix Power Device Management - Unpressurized Docking Mast - Urban Planni |
| UPDM | Universit? Popolare Della Multimedialit? |
| UPF | Universitat Pompeu Fabra (Catalan |
| UPI | United Press International |
| UPN | United Paramount Network |
| UPS | Uninterruptible Power Supply - United Parcel Service |
| UPTN | Universal Personal Telecommunications Number - Upper Peninsula Telehealth Network |
| UPU | Universal Postal Union |
| UR | Soviet Union (NATO Country Code |
| UR | Urdu Language (ISO 639-1 Code) |
| URD | User Requirements Document |
| URD | Urdu Language (ISO 639-2 Code) |
| URI | Uniform Resource Identifier |
| URL | Uniform Resource Locator (earl) |
| URY | Uruguay (ISO 3166 Trigram) |
| US | United States (alsoISO 3166 And FIPS 10-4 Country Code Digram) |
| USA | United States Of America (alsoISO 3166 Trigram) - United States Army |
| USAADAC | U.S. Army Air Defense Artillery Center |
| USAARMC | U.S. Army ARMor Center |
| USAAVNC | U.S. Army AViatioN Center |
| USAF | United States Air Force |
| USAFSPC | U.S. Air Force Space Command |
| USAIC | U.S. Army Infantry Center - U.S. Army Intelligence Center |
| USAID | United States Agency For International Development |
| USAP | Union Sportive Arlequins Perpignan |
| USAPATRIOT | Uniting And Strengthening America By Providing Appropriate Tools Required To Intercept And Obstruct Terrorism |
| USAREUR | United States Army Europe |
| USB | Universal Serial Bus |
| USC | United States Code - University Of South Carolina - University Of Southern California |
| USCG | United States Coast Guard |
| USCINCSPACE | United States Commander In Chief |
| USD | (U.S.) Under-Secretary Of Defense -U.S. Dollar (ISO 4217 Currency Code) |
| USD(A&T) | (U.S.) Under-Secretary Of Defense (Acquisition And Technology) |
| USD(AT&L) | (U.S.) Under-Secretary Of Defense For Acquisition |
| USD(C) | (U.S.) Under-Secretary Of Defense (Comptroller) |
| USD(P&R) | (U.S.) Under-Secretary Of Defense (Personnel & Readiness) |
| USD(P) | (U.S.) Under-Secretary Of Defense (Policy) |
| USDA | United States Department Of Agriculture |