| Acronym | Meaning |
| CHAOS | Cambridge Heart Anti-Oxydant Study |
| CHE | Chechen Language (ISO 639-2 Code) |
| CHE | Switzerland (ISO 3166 Trigram; From Latin Confoederatio Helvetica) |
| CHF | Swiss Franc (ISO 4217 Currency Code) |
| CHI | Computer-Human Interaction |
| CHIP | California Highway Patrol |
| CHIPS | Cosmic Hot Interstellar Plasma Spectrometer |
| CHL | Chile (ISO 3166 Trigram) |
| CHN | China (ISO 3166 Trigram) |
| CHP | California Highway Patrol - Combined Heat And Power |
| CHRS | Canadian Heart Rhythm Society |
| CHS | Combat Health Support |
| CHT | Certified Hand Therapist |
| CHU | Old Church Slavonic Language (ISO 639-2 Code) |
| CHV | Chuvash Language (ISO 639-2 Code) |
| CI | Chile (FIPS 10-4 Country Code) - C?te D'Ivoire (ISO 3166 Digram) -Counter-Intelligence |
| CI | Curie |
| CIA | Cairo International Airport - Central Intelligence Agency - Culinary Institute Of America |
| CIAO | Critical Infrastructure Assurance Office - Component-Integrated ACE ORB |
| CIB | Complete In Box (Internet Auction/trading Listings) |
| CIBC | Canadian Imperial Bank Of Commerce (obsolete) |
| CICS | Customer Information Control System (IBM Mainframe Software; Kicks Or C-I-C-S) |
| CID | Combat Identification -Criminal Investigation Division - Criminal Investigations Department |
| CIEF | Comit? International D'enregistrement Des Fr?quences (International Frequency Registration Board) |
| CIF | Cost |
| CIMIC | Civil-Military Co-operation |
| CIMMYT | Centro Internacional De Mejoramiento De Maz Y Trigo (Spanish |
| CINC | Commander In Chief |
| CINEOS | Campo Imperatore Near-Earth Objects Survey |
| CIO | Chief Information Officer - Congress Of Industrial Organizations |
| CIP | Combat Identification Panel |
| CIPE | (European) Centre For International Political Economy |
| CIR | (Commander's) Critical Information Requirements |
| CIR | Corotating Interaction Region |
| CIS | Canadian Interuniversity Sport - Commonwealth Of Independent States - Command And Information System - Communication And Information System |
| CISA | (U.S.) C4I Integration Support Activity |
| CISB | Complete In Sealed Box (Internet Auction/trading Listings) |
| CISPR | Comit? International Sp?cial Des Perturbations Radio?lectriques (Special International Committee On Radio Interference) |
| CISSP | Certified Information Systems Security Professional |
| CITES | Convention On International Trade In Endangered Species (of Wild Fauna And Flora) (sigh-tease) |
| CITS | Combat Identification Training System |
| CIV | C?te D'Ivoire (ISO 3166 Trigram) |
| CIVPOP | Civilian Population |
| CIWS | Close-In Weapon System |
| CI | Commission Internationale De L'?clairage |
| CJ | Cayman Islands (FIPS 10-4 Country Code) -Criminal Justice |
| CJC | Canadian Jewish Congress |
| CJCS | Chairman |
| CJD | Chronological Julian Day - Creutzfeldt-Jakob Disease |
| CJO | Chief Of Joint Operations |