| Acronym | Meaning |
 | DR | Dead Reckoning -Dominican Republic (FIPS 10-4 Country Code) -Danmarks Radio (Danish Broadcasting Corporation) |
| DRA | Defence Research Agency (UK |
| DRAGN | Double Radio Source Active Galactic Nucleus (dragon) |
| DRAM | Dynamic Random Access Memory (dee-ram) (computing) |
| DRC | Democratic Republic Of The Congo |
| DRDC | Defence Research & Development Canada |
| DREA | Defence Research Establishment Atlantic (obsolete 2002) |
| DRES | Defence Research Establishment Suffield (obsolete 2002) |
| DRET | Defence Research Establishment Toronto (obsolete 2002) |
| DREV | Defence Research Establishment Valcartier (obsolete 2002) |
| DRI | Detection |
| DRIC | (U.S.) Defense Research Information Center |
| DRL | Daytime Running Lights - Dorman Roberts Ltd. |
| DRM | Digital Rights Management |
| DRMS | (U.S.) Defense Revitalization And Marketing Service |
| DRPR | Drawing Practices |
| DRT | Document Related Technologies |
| DS | Dear Son (increasingly Prevalent On Social Mailing Lists |
| DS | Darmstadtium |
| DSA | (U.S.) Defense Support Activities - Division Support Area |
| DSAA | (U.S.) Defense Security Assistance Agency |
| DSB | (U.S.) Defense Science Board |
| DSC | Differential Scanning Calorimeter - Digital Selective Calling - Digital Still Camera - Distinguished Service Cross - Doctor Of Surgical Chiropody (obsolete) - Document Structure Convention (PostScript Programming) - Dynamic Stability Control |
| DSCS | U.S. Defense Satellite Communications System |
| DSCSOC | DSCS Operations Center |
| DSD | Defence Studies Department (King's College |
| DSG | (i) Direct-Shift Gearbox |
| DSID | Dismounted Soldier Identification System |
| DSM | Diagnostic And Statistical Manual Of Mental Disorders |
| DSN | Deep Space Network |
| DSO | Distinguished Service Order (British Military Decoration) |
| DSP | Decessit Sine Prole (Latin |
| DSP | Defense Standardization Program - Defense Support Program - Digital Signal Processing |
| DSPL | D.s.p. Legitima (Latin |
| DSPL | Design Specialists And Plans Language |
| DSPM | D.s.p. Malus (Latin |
| DSPML | D.s.p.m. Legitima (Latin |
| DSPMS | D.s.p.m. Suivre (Latin |
| DSPS | D.s.p. Suivre (Latin |
| DSR | Deformed Special Relativity |
| DSRV | Deaf Sports Recreation Victoria - Deep Submergence Rescue Vehicle |
| DSS | Digitized Sky Survey - Discarding-Sabot Shell (ammunition) |
| DST | Daylight Saving Time |
| DSTL | British Defence Science And Technology Laboratory |
| DSWA | (U.S.) Defense Special Weapons Agency |
| DTD | Digital Terrain Data |
| DTE | Data Terminal Equipment - Down To Earth |
| DTED | Digital Terrain Elevation Data (dee-ted) |
| DTG | Date-Time Group |
| DTH | Direct To Home (television) |
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