| Acronym | Meaning |
| DTI | UK Department Of Trade And Industry |
| DTIC | (U.S.) Defense Technical Information Center |
| DTL | Diode-Transistor Logic (electronics) |
| DTLOMS | Doctrine |
| DTO | Disruptive Technology Office (was ARDA) |
| DTOMLS | Doctrine |
| DTRA | Defense Threat Reduction Agency (deet-ra) |
| DTSA | (U.S.) Defense Technology Security Administration |
| DU | Depleted Uranium -Dust (METAR Code) |
| DUI | Data Use Identifier - Data Use Institute - Davis Unified Ignition - Diving Unlimited International - Documento ?nico De Identidad - Documento Unico De Importaci›n - Driving Under The Influence - Duke University Improv |
| DUSD | (U.S.) Deputy Under-Secretary Of Defense |
| DV | Daily Value (FDA Food Guide) - Deo Volente (Latin |
| DV | Dhivehi Language (ISO 639-1 Code) |
| DVD | Digital Versatile Disk (was Digital Video Disk) |
| DVLC | UK Driver And Vehicle Licencing Centre |
| DVM | Decessit Vita Matris (Latin |
| DVM | Doctor Of Veterinary Medicine |
| DVO | Direct View Optics |
| DVP | Decessit Vita Patris (Latin |
| DVU | Decessit Vita Uxoris (Latin |
| DW | Drum Workshop |
| DWG | Divisional Wargame (military Simulation) |
| DWI | Dance With Intensity - Danish West Indies - Diffusion-weighted Imaging - Direct Water Injection - Disaster Welfare Inquiry - Drinking Water Inspectorate - Driving While Intoxicated/Impaired |
| DWIM | Do What I Mean |
| DX | Dexterity (role-playing Games) -DeXtrorphan - Distant (radio) -D-Generation X (professional Wrestling) |
| DXA | Dual-energy X-ray Absorptiometry |
| DXM | DeXtroMethorphan |
| DY | Dahomey (ISO 3166 Digram; Obsolete Since 1977) |
| DY | Dysprosium |
| DZ | Algeria (ISO 3166 Digram) - Drizzle (METAR Code) -Drop Zone |
| DZ | Dzongkha Language (ISO 639-1 Code) |
| DZA | Algeria (ISO 3166 Trigram) |
| DZD | Algerian Dinar (ISO 4217 Currency Code) |
| DZO | Dzongkha Language (ISO 639-2 Code) |
| E | East |
| E&E | Escape And Evasion (training) |
| E&OE | Errors And Omissions Excepted |
| E.G. | Exampla Gratia (Latin |
| E? OR E3 | Many |
| EA | Electronic Attack - Engagement Area - Electronic Arts - Environmental Assessment -Exaampere |
| EABU | Explain Acronyms Before Use |
| EAC | Echelons Above Corps |
| EAFUS | Everything Added To Food In The United States (FDA List) |
| EAPC | Euro-Atlantic Partnership Council |
| EASA | European Aviation Safety Agency |
| EAST | Experimental Advanced Superconducting Tokamak |
| EBCDIC | Extended Binary Coded Decimal Interchange Code (pronounced Eb-see-dik) (cf. BCD) |
| EBD | Electronic Brake Distribution |
| EBE | Extraterrestrial Biological Entity |
| EBO | Effects Based Operations - Encyclop?dia Britannica Online - European Board Of Ophthalmology |