| Acronym | Meaning |
| GNAS | Grand National Archery Society |
| GNB | Guinea-Bissau (ISO 3166 Trigram) |
| GNF | Guinean Franc (ISO 4217 Currency Code) |
| GNOME | GNU Network Object Model Environment |
| GNP | Gross National Product |
| GNQ | Equatorial Guinea (ISO 3166 Trigram) |
| GNRH | Gonadotropin-Releasing Hormone |
| GNU | GNU's Not Unix |
| GO | Glorioso Islands (FIPS 10-4 Territory Code) |
| GOA | General Of The Army (United States Only) -Gun Owners Of America |
| GOC | General Officer Commanding |
| GOES | Geostationary Operational Environmental Satellite |
| GOMER | Get Out Of My Emergency Room (derogatory Reference To Hypochondriac Patients) |
| GOP | Grand Old Party |
| GORP | Granola |
| GOSC | General Officer Steering Committee |
| GOSH | Great Ormond Street Hospital |
| GOSP | Gas/Oil Separation Plant |
| GOTS | Government Off The Shelf |
| GOYADIN | Get Off Your Arse |
| GP | General Practitioner - General Purpose - Grand Prix -Guadeloupe (ISO 3166 Digram; FIPS 10-4 Territory Code) |
| GPA | Grade Point Average |
| GPC | Global Path Cache |
| GPG | GNU Privacy Guard |
| GPIB | General-Purpose Instrumentation/Interface Bus |
| GPL | General Public License |
| GPMP | General Purpose Macro Processor |
| GPO | General Post Office |
| GPPC | Genetics And Public Policy Center |
| GPR | Ground-Penetrating Radar |
| GPS | General Problem Solver - Global Positioning System |
| GPT | GEC-Plessey Telecommunications - General Purpose Technology - Get Paid To Website |
| GPU | Gosudarstvennoye Politicheskoye Upravlenie (Russian ??????????????? ???????????? ?????????? |
| GQ | Equatorial Guinea (ISO 3166 Digram) -Gentlemen's Quarterly (magazine) -Guam (FIPS 10-4 Territory Code) |
| GR | Greece (FIPS 10-4 Country Code; ISO 3166 Digram) - Hail (METAR Code) |
| GRAS | Generally Regarded As Safe (FDA List) |
| GRB | Gamma-Ray Burst |
| GRC | Greece (ISO 3166 Trigram) |
| GRD | Grenada (ISO 3166 Trigram) |
| GREP | [search] Globally For Regular Expression |
| GRID | Gay-Related Immune Deficiency (original Name Of AIDS) |
| GRL | Greenland (ISO 3166 Trigram) |
| GRN | Guaran Language (ISO 639-2 Code) |
| GRP | Graphite Reinforced Plastic |
| GS | R -General Support-Reinforcing |
| GS | General Support -Gigasiemens - South Georgia And The South Sandwich Islands (ISO 3166 Digram) |
| GS | Gigasecond |
| GSA | U.S. General Services Administration |
| GSD | Graphical Situation Display |
| GSK | GlaxoSmithKline |