| Acronym | Meaning |
| ICBM | Intercontinental Ballistic Missile |
| ICBN | International Code Of Botanical Nomenclature |
| ICC | Integrated Command And Control - International Criminal Court - International Cricket Council - Interstate Commerce Commission |
| ICD | Implantable Cardioverter-Defibrillator - Initial Capabilities Document - International Classification Of Diseases |
| ICES | International Council For The Explorationof The Seas |
| ICF | Intelligent Community Forum |
| ICHTHYS | Iesous Christos |
| ICM | Improved Conventional Munition - Integrated Collection Management - International Congress Of Mathematicians - Iraq Campaign Medal |
| ICMP | Internet Control Message Protocol |
| ICNAF | International Commission For The Northwest Atlantic Fisheries (became NAFO In 1978) |
| ICNI | Integrated Communication |
| ICO | Intermediate Circular Orbit |
| ICP | Inductively Coupled Plasma - Insane Clown Posse |
| ICRAF | International Centre For Research In Agroforestry (a.k.a. World Agroforestry Centre Since 2002) |
| ICRISAT | International Crops Research Institute For The Semi-Arid Tropics |
| ICRL | Individual Component Repair List |
| ICRS | International Celestial Reference System |
| ICS | In-Country Support - Intelligence And Communications Systems - Interim Contractor Support |
| ICSI | Intracytoplasmic Sperm Injection |
| ICTH | Island Closest To Heaven/Hell Final Fantasy VIII |
| ICV | Infantry Carrier Vehicle |
| ICW | In Co-ordination With - Indonesia Corruption Watch - Infectious And Chemotherapeutic Waste - Insulating Concrete Wall - Integral Crystalline Waterproofing -Interactive Courseware |
| ICZN | International Code Of Zoological Nomenclature - International Commission On Zoological Nomenclature |
| ID | Idaho (postal Symbol) -Identity -Indonesia (FIPS 10-4 Country Code; ISO 3166 Digram) -Infantry Division - Intelligent Design |
| ID | Indonesian Language (ISO 639-1 Code) |
| IDA | U.S. Institute For Defense Analyses - International Development Association (part Of The World Bank |
| IDC | International Data Corporation |
| IDE | Integrated Development Environment - Integrated Drive Electronics |
| IDEA | Individuals With Disabilities Education Improvement Act |
| IDF | Israel Defence Forces - Intel Development Forum - International Dairy Federation |
| IDL | Interface Definition Language |
| IDN | Indonesia (ISO 3166 Trigram) |
| IDO | Ido Language (ISO 639-2 Code) |
| IDR | Indonesian Rupiah (ISO 4217 Currency Code) |
| IE | Indo-European Languages - Internet Explorer -Ireland (ISO 3166 Digram) |
| IE | Interlingue Language (ISO 639-1 Code) |
| IEA | International Energy Agency |
| IEC | International Electrotechnical Commission |
| IED | Improvised Explosive Device |
| IEEE | Institute Of Electrical And Electronics Engineers (I Triple-E) |
| IELTS | International English Language Testing System |
| IER | Information Exchange Requirement |
| IET | Initial Entry Training |
| IETF | Internet Engineering Task Force |
| IEW | Intelligence And Electronic Warfare |
| IFAH | International Federation For Animal Health |
| IFAP | International Federation Of Agricultural Producers |
| IFC | International Finance Corporation (part Of The World Bank) -Independent Film Channel |
| IFF | Identification |
| IFFN | Identification |