| Acronym | Meaning |
 | LRICBM | Limited Range ICBM |
| LRIP | Low Rate Initial Production |
| LRP | Logistics Release Point |
| LRPE | Long-Range Planning Element |
| LRS | Long Range Surveillance |
| LRU | Line-Replaceable Unit |
| LS | Landing Support -Lesotho (ISO 3166 Digram) - Liechtenstein (FIPS 10-4 Country Code) -locus Sigilli (Latin |
| LSD | Landing Ship |
| LSE | Least Squares Estimate/Error - London School Of Economics - London Stock Exchange |
| LSI | Large-Scale Integration |
| LSIF | Labour Sponsored Investment Fund |
| LSL | Lesotho Loti (ISO 4217 Currency Code) |
| LSND | Liquid Scintillator Neutrino Detector |
| LSO | Lesotho (ISO 3166 Trigram) |
| LSST | Large Synoptic Survey Telescope |
| LST | Landing Ship |
| LSVW | Light Support Vehicle |
| LT | Lesotho (FIPS 10-4 Country Code) - Lithuania (ISO 3166 Digram) |
| LT | Lieutenant |
| LT | Lithuanian Language (ISO 639-1 Code) |
| LTC | Long Term Costing |
| LTC | Lieutenant-Colonel (U.S.) |
| LTD | Limited |
| LTDP | Long-Term Defence Plan |
| LTG | Lieutenant General -Lightning (METAR Code) |
| LTI | Linear Time-Invariant |
| LTL | Lithuanian Litas (ISO 4217 Currency Code) |
| LTP | Long-Term Potentiation |
| LTU | Lithuania (ISO 3166 Trigram) |
| LTZ | Luxembourgish Language (ISO 639-2 Code) |
| LU | Lutetium |
| LU | Tshiluba Language (ISO 639-1 Code) |
| LU | Loonatics Unleashed |
| LUB | Tshiluba Language (ISO 639-2 Code) |
| LUCA | Last Universal Common Ancestor |
| LUG | Linux User Group |
| LUG | Luganda Language (ISO 639-2 Code) |
| LULU | Locally Unwanted Land Use (urbanism) |
| LUT | Limited User Test(ing) - Local User Terminal |
| LUVW | Light Utility Vehicle |
| LUX | Luxembourg (ISO 3166 Trigram) |
| LV | Las Vegas -Latvia (ISO 3166 Digram) -Launch Vehicle - Leading Vehicle -Leave -Left Ventricle - Level Valve - Linking Verb |
| LV | Latvian Language (ISO 639-1 Code) |
| LVA | Latvia (ISO 3166 Trigram) |
| LVEF | Left Ventricular Ejection Fraction |
| LVL | Latvian Lats (ISO 4217 Currency Code) |
| LW | Land Warrior - Low Water (nautical Charts) |
| LW | Lawrencium (obsolete 1963) |
| LWR | Laser Warning Receiver |
| LWS | Land Warrior System |
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