| Acronym | Meaning |
| LX | Luxembourg (amateur Radio ITU Prefix) - Swiss International Airlines (IATA Code) |
| LY | Libya (FIPS 10-4 Country Code; ISO 3166 Digram) - Lithuania (amateur Radio ITU Prefix) |
| LYAO | Laugh Your Ass Off |
| LYD | Libyan Dinar (ISO 4217 Currency Code) |
| LYLAS | Love You Like A Sister |
| LZ | Bulgaria (amateur Radio ITU Prefix) -Landing Zone |
| M | Mega - One Thousand (in Roman Numerals) |
| M | Metre - Milli |
| M&S | Modelling & Simulation - Marks & Spencer |
| MA | Master Of Arts -Madagascar (FIPS 10-4 Country Code) - Massachusetts (postal Symbol) - Megaampere - Morocco (ISO 3166 Digram) |
| MA | Megaannum |
| MA | Milliampere |
| MAA | Mathematical Association Of America |
| MAAMAW | Modelling Autonomous Agents In A Multi-Agent World |
| MAC | Macao (ISO 3166 Trigram) -U.S. Military Airlift Command (1966-1992) |
| MACA | Military Aid To The Civil Authorities |
| MACE | Multi-Agent Computing Environment |
| MACHO | MAssive Compact Halo Object |
| MAD | Magnetic Anomaly Detector -Moroccan Dirham (ISO 4217 Currency Code) -Mutual Assured Destruction |
| MADD | Mothers Against Drunk Driving - MyoAdenylate Deaminase Deficiency -Multiply-Add |
| MAF | Maintenance Action Form |
| MAGIC | Major Atmospheric Gamma-ray Imaging Cherenkov (telescope) |
| MAGNETAR | Metaprogrammable AGent NETwork ARchitecture |
| MAGTF | Marine Air-Ground Task Force |
| MAH | Marshallese Language (ISO 639-2 Code) |
| MAL | Malayalam Language (ISO 639-2 Code) |
| MALD | Miniature Air-Launched Decoy |
| MANPADS | MAN-Portable Air Defence System |
| MANPRINT | MANpower And PeRsonnel INTegration |
| MAO | Mol?t? Astronomijos Observatorija (Moletai Astronomical Observatory) - MonoAmine Oxidase |
| MAPS | Monitoring Avian Productivity And Survivorship |
| MAQS | Museum Of The American Quilter's Society (max) |
| MAR | Marathi Language (ISO 639-2 Code) |
| MAR | Morocco (ISO 3166 Trigram) |
| MARBEF | Marine Biodiversity And Ecosystem Functioning |
| MARC | MAchine Readable Cataloging (often Also Defined As MAchine Readable Code) |
| MARCENT | United States Marine Forces Central Command |
| MARFORCC | Marine Force Component Commander |
| MAS | NATO Military Agency For Standardisation |
| MASAS | Monte Agliale Supernovae And Asteroid Survey |
| MASER | Microwave Amplification By Stimulated Emission Of Radiation |
| MASH | Mobile Army Surgical Hospital |
| MASINT | Measurement And Signature Intelligence |
| MATREX | Modeling Architecture For Technology |
| MATS | U.S. Military Air Transport Service (1948-1966) |
| MAVS | Mobile Artillery Vehicle System |
| MAX | Meta-reasoning Architecture For X |
| MB | Manitoba (postal Symbol) - Martinique (FIPS 10-4 Territory Code) |
| MBA | Main Battle Area - Main Belt Asteroid - Masters Of Business Administration |
| MBBL | (U.S. Armor Center) Mounted Battlespace Battle Laboratory |