| Acronym | Meaning |
 | MODAF | Ministry Of Defence Architecture Framework (moh-daff) |
| MODEM | Modulator-Demodulator |
| MODSAF | Modular Semi-Automated Forces (military Simulation) |
| MOE | Marvel Of Entertainment |
| MOE | Measure Of Effectiveness |
| MOF | Ministry Of Finance (Japan) |
| MOFA | Ministry Of Foreign Affairs (Japan) |
| MOH | Medal Of Honor - Music On Hold |
| MOID | Minimum Orbital Intersection Distance |
| MOL | Moldovan Language (ISO 639-2 Code) - Mole (unit) |
| MOLO | Mobile Other Licenced Operator (UK) |
| MOM | Management Object Model (HLA) - Message Oriented Middleware |
| MOMA | Museum Of Modern Art (NYC) |
| MON | Mongolian Language (ISO 639-2 Code) |
| MOND | Modified Newtonian Dynamics |
| MOO | Measure Of Outcome |
| MOOTW | Military Operations Other Than War (moot-double-you) |
| MOP | Macau Pataca (ISO 4217 Currency Code) -Measure Of Performance |
| MOPE | Ministry Of Population And Environment (Nepal) - Most Oppressed People Ever (politics) |
| MOPP | Mission-Oriented Protective Posture |
| MORP | Meteorite Observation And Recovery Project |
| MORS | Military Operations Research Society |
| MOS | Military Occupational Specialty -Mit Out Sound / Motor Only Sync -Mobile Object System - Model Output Statistics - Multiplayer Online Services |
| MOSFET | Metal-Oxide-Semiconductor Field-Effect Transistor |
| MOSS | MObile Submarine Simulator -Moving Object Support System |
| MOT | Ministry Of Transport (UK) |
| MOTA | Member Of The Orthodontic Technicians Association |
| MOTESS | Moving Object And Transient Event Search System |
| MOTO | Mail Order / Telephone Order - Master Of The Obvious |
| MOU | Memorandum Of Understanding |
| MOUT | Military Operations In Urban[ized] Terrain |
| MOVES | Modeling |
| MOW | Maintenance Of Way (also MW) |
| MOZ | Mozambique (ISO 3166 Trigram) |
| MP | Magic Points -Mauritius (FIPS 10-4 Country Code) -Member Of Parliament - Military Police - Missouri Pacific -Northern Mariana Islands (postal Symbol; ISO 3166 Digram) |
| MPA | Maritime Patrol Aircraft - Master Of Public Administration |
| MPA | Megapascal |
| MPA | Millipascal |
| MPAA | Motion Picture Association Of America |
| MPC | Minor Planet Center - Minor Planet Circular |
| MPEC | Minor Planet Electronic Circular |
| MPEG | Motion Pictures (Coding) Experts Group |
| MPEV | Multi-Purpose Engineering Vehicle |
| MPF | Maritime Prepositioning Force |
| MPFC | Medial PreFrontal Cortex |
| MPMC | Medial PreMotor Cortex |
| MPSI | Member Of The Pharmaceutical Society Of Ireland |
| MPSOC | MultiProcessor System-on-Chip |
| MPSRON | Maritime Propositioning Ship Squadron |
| MQ | Martinique (ISO 3166 Digram) - Midway Islands (FIPS 10-4 Territory Code) |
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