| Acronym | Meaning |
| NW | Nuclear Weapon |
| NW | Nanowatt |
| NW | North-West |
| NWA | National Wrestling Alliance |
| NWF | National Wildlife Federation |
| NWFZ | Nuclear-Weapon-Free Zone |
| NWHN | U.S. National Women's Health Network |
| NWO | New World Order (see Article For Explanation Of Idiosyncratic Capitalization) |
| NWRA | National Wildlife Rehabilitators Association |
| NWT | North-West Territories |
| NY | Chichewa Language (ISO 639-1 Code) |
| NY | New York (postal Symbol) |
| NYA | Chichewa Language (ISO 639-2 Code) |
| NYHA | New York Heart Association |
| NYO | National Youth Orchestra Of Great Britain |
| NYRA | National Youth Rights Association -New York Racing Association (horse Racing) |
| NYSE | New York Stock Exchange |
| NYT | New York Times |
| NZ | New Zealand (ISO 3166 And FIPS 10-4 Country Code Digram) |
| NZC | New Zealand Cricket |
| NZD | New Zealand Dollar (ISO 4217 Currency Code) |
| NZL | New Zealand (ISO 3166 Trigram) |
| NZL | Noze Looan (online/event Listings) |
| O | Oberst - Observer - Obstacle - Octal - Officer - Official - Oh - Operational - Operator - Oprah (magazine) - Outstanding -Oxygen |
| OA | Operational Analysis |
| OAC | On Approved Credit |
| OARSI | Osteoarthritis Research Society International |
| OAS | Organization Of American States |
| OASIS | Objects And Agents For Information Systems And Simulation - Organization For The Advancement Of Structured Information Standards |
| OASIS | Ontario Agencies Supporting Individuals With Special Needs |
| OASIS | Ontario Association Of Sewage Industry Services |
| OASP | Operational Analysis Support Paper/Plan |
| OAU | Organization For African Unity |
| OB | Obedience - Obligation - Obligatory - Obsolete - Obstetrics -Ocean Beach (California) - Off Break (cricket) - Old Bryanstonian - Order Of Battle - Outlet Box (electrical) -Overbought (stock Market) -Oversight Board |
| OB | Obiit (Latin |
| OBE | Officer Of The Order Of The British Empire |
| OBJ | Objective (military Parlance) |
| OBS | Observation/Observer - Obsolete - Obstacle -Off Balance Sheet - Optical Burst Switching (IEEE) - Organic Brain Syndrome - Organization(al) Breakdown Structure |
| OBSS | Off Board Sensor Systems - Ordo Byantinus Sancti Sepulchri (Byzantine Order Of The Holy Sepulchre) - Orbiter Boom Sensor System (space Shuttle) - Origins Billion Star Survey |
| OBX | Outer Banks (North Carolina) |
| OC | Observer/Controller |
| OC | Occitan Language (ISO 639-1 Code) |
| OCA | Observatoire De La C?te D'Azur - Offensive Counter-Air |
| OCD | Obsessive-Compulsive Disorder |
| OCFS | Oracle Cluster File System |
| OCFS2 | Oracle Cluster File System Release 2 |
| OCI | Occitan Language (ISO 639-2 Code) |
| OCIDS | Optical Combat Identification System |
| OCN | Oncology Certified Nurse |
| OCO | Oort Cloud Object |