| Acronym | Meaning |
| RCHA | Royal Canadian Horse Artillery (regiment) |
| RCMP | Royal Canadian Mounted Police |
| RCRA | Resource Conservation And Recovery Act (reck-ra Or Rick-ra) |
| RCS | Radar Cross-Section - Revision Control System - Reaction Control System |
| RCT | Randomized Controlled Trial - Robotically Controlled Telescope |
| RCZ | Rear Combat Zone |
| RD | Radio Disney |
| RDA | Research |
| RDD | Radiological Dispersion Device |
| RDDL | Resource Directory Description Language (riddle) |
| RDECOM | (U.S.) Research |
| RDM | Remotely Delivered/Deliverable Mine |
| RDO | Rapid |
| RDT | Remote Digital Terminal |
| RDTE OR RDT&E | Research |
| RDV | Remote Detection Vehicle |
| RE | Rhenium |
| RE | Royal Engineers |
| REACH | Registration |
| REACT | Remote Electronically Activated Control Technology |
| REAM | Retired Educators Association Of Minnesota |
| REEF | Reef Environmental Education Foundation |
| REM | Rapid Eye Movement (sleep Phase) - Rosicrucian Egyptian Museum |
| REME | Royal Electrical And Mechanical Engineers |
| RERC | Rehabilitation Engineering Research Center |
| RES | Radiation Exposure Status -Reserve |
| RESNA | Rehabilitation Engineering And Assistive Technology Society Of North America |
| REU | R?union (ISO 3166 Trigram) |
| RF | Radio Frequency - Receptive Field (neurophysiology) |
| RF | Rutherfordium |
| RFA | Restrictive Fire Area (military) - Royal Field Artillery |
| RFC | Request For Comments - Royal Flying Corps (WWI Precursor To RAF) |
| RFE | Request For Enhancement |
| RFEF | Real Federaci›n Espa?ola De Fœtbol (Spanish For Royal Spanish Football Federation) |
| RFI | Ready For Inspection - Ready For Issue - Request For Information - Radio Frequency Interference |
| RFID | Radio Frequency IDentification |
| RFL | Restrictive Fire Line (military) |
| RG | Republican Guard |
| RG | Roentgenium |
| RGB | Red Green Blue (colour Model) |
| RGBI | Red Green Blue Intensity (ditto) |
| RH | Rhodium |
| RH | Southern Rhodesia (ISO 3166 Digram; Obsolete 1980) |
| RHIC | Relativistic Heavy Ion Collider |
| RHLI | Royal Hamilton Light Infantry (Canadian Militia Regiment) |
| RHO | Southern Rhodesia (ISO 3166 Trigram; Obsolete 1980) |
| RHS | Right Hand Side - Redland High School |
| RHU | Replacement Holding Unit |
| RHWR | Radar Homing And Warning Receiver (raw For Short) |
| RI | Rhode Island (postal Symbol) |