| Acronym | Meaning |
 | SARS | Severe Acute Respiratory Syndrome |
| SART | Situational Awareness Rating Technique |
| SAS | Scandinavian Airline Systems - Second Avenue Subway - Situational Awareness System - Special Air Service - Studies |
| SASE | Self-Addressed Stamped Envelope |
| SASO | Stability And Support Operations |
| SASOL | Suid Afrikaanse Steenkool En Olie (Afrikaans |
| SAT | Formerly Scholastic Aptitude Test And Scholastic Assessment Test; Now Known Solely By The Initials - Small Arms Trainer |
| SATB | Soprano Alto Tenor Bass |
| SAU | Saudi Arabia (ISO 3166 Trigram) |
| SAVAK | Sazamane Etelaat Va Amniate Kechvar (Iranian Security And Intelligence Service) |
| SAW | Squad Automatic Weapon - Surface Acoustic Wave |
| SAWE | Society Of Allied Weight Engineers |
| SB | Sexy Bitch - Sexy Bastard - Sexy Boy |
| SB | Antimony (Latin Stibium) |
| SB | Solomon Islands (ISO 3166 Digram) |
| SBA | Simulation-Based Acquisition - Sovereign Base Area |
| SBB | German For The Swiss Federal Railways |
| SBC | Sensotronic Brake Control - Single-Board Computer |
| SBCCOM | U.S. Army Soldier And Biological Chemical Command (disbanded 2003) |
| SBCS | Single-Byte Character Set |
| SBCT | Stryker Brigade Combat Team |
| SBD | Solomon Islands Dollar (ISO 4217 Currency Code) |
| SBS | Special Boat Service - Special Broadcasting Service |
| SC | Cruiser Submarine (US Navy Hull Classification) - Saint Kitts And Nevis (FIPS 10-4 Country Code; From Saint Christopher) - Seychelles (ISO 3166 Digram) - South Carolina (postal Symbol) |
| SC | Sardinian Language (ISO 639-1 Code) |
| SC | Scandium |
| SCAP | Supreme Commander Allied Powers (Allied Occupation Of Japan) |
| SCCM | Standard Cubic Centimetre Per Minute (unit Of Measurement Of Fluid Flow) |
| SCCS | Standard Cubic Centimetre Per Second (unit Of Measurement Of Fluid Flow) |
| SCFH | Standard Cubic Foot Per Hour (unit Of Measurement Of Fluid Flow) |
| SCFM | Standard Cubic Foot Per Minute (unit Of Measurement Of Fluid Flow) |
| SCFS | Standard Cubic Foot Per Second (unit Of Measurement Of Fluid Flow) |
| SCG | Serbia And Montenegro (ISO 3166 Trigram) |
| SCHIMS | Soldier Combat Helmet Identification Marking System |
| SCIFI | Science Fiction |
| SCJD | Sporadic Creutzfeldt-Jakob Disease |
| SCM | Surface Contamination Module |
| SCN | Suprachiasmatic Nucleus |
| SCNT | Somatic Cell Nuclear Transfer |
| SCO | Scotland |
| SCOTUS | Supreme Court Of The United States |
| SCR | Seychelles Rupee (ISO 4217 Currency Code) |
| SCRAM | Safety Control Rod Axe Man |
| SCS | Scan Correlated Shift - Soil Conservation Service |
| SCSI | Small Computer System Interface (scuzzy) -Strategic And Combat Studies Institute |
| SCT | Scattered Sky (METAR Code) |
| SCTP | Stream Control Transmission Protocol |
| SCUBA | Self Contained Underwater Breathing Apparatus |
| SCUFN | Sub-Committee On Undersea Feature Names (of GEBCO) |
| SD | Sheriff's Department - Smoke/Decontamination-South Dakota (postal Symbol) - Sudan (ISO 3166 Digram) |
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