| Acronym | Meaning |
 | SOUTHAG | Southern Army Group |
| SOUTHCOM | (U.S.) Southern Command |
| SOV | Single Occupant Vehicle |
| SOW | Statement Of Work |
| SOWHAT | RESNA Subcommittee On Wheelchairs And Transportation |
| SOX | Sarbanes-Oxley |
| SP | Security Police - Self-Propelled - Shore Patrol -Spain (FIPS 10-4 Country Code) -Start Point - Strong Point |
| SP | Special - Spring Tide (nautical Charts) |
| SPA | Spanish Language (ISO 639-2 Code) |
| SPAAG | Self-Propelled Anti-Aircraft Gun |
| SPACECOM | (U.S.) Space Command |
| SPC | Secretariat Of The Pacific Community |
| SPCO | Single-Pole Change Over |
| SPD | Shimano Pedaling Dynamics - Sozialdemokratische Partei Deutschlands (Social Democratic Party Of Germany) |
| SPDT | Single-Pole Double-Throw |
| SPEAC | Stop Primate Experiments At Cambridge (later Became SPEAK) |
| SPEED | Subsistence Preparation By Electronic Energy Diffusion (early Military Microwave Oven) |
| SPIE | Originally The Society For Photo-Optical Instrumentation Engineers (SPIE - The International Society For Optical Engineering 1981?2007 |
| SPL | #NAME? |
| SPM | Saint Pierre And Miquelon (ISO 3166 Trigram) |
| SPOD | Sea Port Of Debarkation |
| SPOE | Sea Port Of Embarkation |
| SPOT | Satellite Pour L'observation De La Terre (French |
| SPQR | Senatus Populus Que Romanus (Latin The Senate And The People Of Rome) |
| SPS | Sine Prole Superstite (Latin |
| SPS | Standard Positioning Service (GPS) |
| SPST | Single-Pole Single-Throw |
| SQ | Albanian Language (ISO 639-1 Code) |
| SQ | Sound Quality |
| SQI | Albanian Language (ISO 639-2 Code) |
| SQL | Structured Query Language (seek-well) |
| SQN | Squadron |
| SQUID | Superconducting QUantum Interference Device |
| SR | ATGW -Short-Range Anti-Tank Guided Weapon |
| SR | Sound Reinforcement - Supply Route -Suriname (ISO 3166 Digram) -Sveriges Radio (Swedish Radio Ltd) |
| SR | Serbian Language (ISO 639-1 Code) |
| SR | Strontium |
| SRAM | Static Random Access Memory (ess-ram) |
| SRB | Solid Rocket Booster |
| SRBM | Short-Range Ballistic Missile (cf. IRBM |
| SRC | Scheduled Removal Component |
| SRD | Science Requirements Document -Surinam Dollar (ISO 4217 Currency Code) |
| SRD | Sardinian Language (ISO 639-2 Code) |
| SREL | Savannah River Ecology Laboratory |
| SRG | SACEUR Rover Group - Special Republican Guard |
| SRGW | Short-Range Guided Weapon |
| SRL | Savannah River Laboratory - Single Rocket Launcher - Survival Research Labs |
| SRM | Specified Risk Material |
| SRP | Serbian Language (ISO 639-2 Code) |
| SRS | Savannah River Site |
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