| Acronym | Meaning |
 | ORR | Office Of Refugee Resettlement |
| ORWH | Office Of Research On Women's Health |
| OSAC | Overseas Security Advisory Council |
| OSBP | Office Of Small Business Programs |
| OSC | Office Of Special Counsel |
| OSCE | Office Of Child Support Enforcement |
| OSDBU | Office Of Small And Disadvantaged Business Utilization |
| OSERS | Office Of Special Education And Rehabilitative Services |
| OSF | Office Of Space Flight |
| OSHA | Occupational Safety And Health Administration |
| OSHRC | Occupational Safety And Health Review Commission |
| OSM | Office Of Surface Mining; Office Of Spectrum Management |
| OST | Office Of Science And Technology; Office Of The Secretary Of Transportation |
| OSTI | Office Of Scientific And Technical Information |
| OSTP | Office Of Science And Technology Policy |
| OSWER | Office Of Solid Waste And Emergency Response |
| OTA | Office Of Technology Assessment |
| OTJ | Office Of Tribal Justice |
| OTS | Office Of Thrift Supervision |
| OTT | Office Of Transportation Technologies |
| OVAE | Office Of Vocational And Adult Education |
| OVC | Office For Victims Of Crime |
| OWBO | Office Of Women's Business Ownership |
| OWCP | Office Of Workers' Compensation Programs |
| OWH | Office On Women's Health |
| PAHO | Pan American Health Organization |
| PAM | Office Of Acquisition And Property Management |
| PBGC | Pension Benefit Guaranty Corporation |
| PBS | Public Buildings Service |
| PC | Peace Corps |
| PCBE | President's Council On Bioethics |
| PCC | Panama Canal Commission |
| PCIE | President's Council On Integrity And Effiency |
| PFIAB | President's Foreign Intelligence Advisory Board |
| PHA | Public Housing Agency |
| PHN | Center For Population |
| PHPPO | Public Health Practice Program Office |
| PHPS | Public Health Prevention Service |
| PHS | Public Health Service |
| PHTN | Public Health Training Network |
| PIH | Office Of Public And Indian Housing |
| PLLI | National Institute On Postsecondary Education |
| PNNL | Pacific Northwest National Laboratory |
| POW/MP | Prisoner Of War/Missing Personnel |
| PPQ | Plant Protection And Quarantine |
| PRC | Postal Rate Commission |
| PRM | Bureau Of Population |
| PSC | Program Support Center |
| PTO | Patent And Trademark Office |
| PUMS | Public Use Microdata Samples |
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