| Acronym | Meaning |
 | SCF | Scheduled Change Factor (milestone Modifier) |
| SCFE | Subcontractor Furnished Equipment |
| SCHLT | Search Light |
| SCI | Serial Communication Interface |
| SCI | Supplemental Card Indicator |
| SCM | Simulator Operations And Maintenance |
| SCM | Software Configuration Management |
| SCMP | Software Configuration Management Plan |
| SCMT | Ship Control Maintenance Trnr (trident-11d99) |
| SCN | Specification Change Notice |
| SCOT | Ship Control Operator Trnr (trident-21c10) |
| SCP | Single Card Processor |
| SCP | Software Change Proposal |
| SCP | Supplier Change Proposal |
| SCPB | F-14 Software Change Proposal Board |
| SCPM | Stars Composite Process Model |
| SCR | Silicon Control Rectifier |
| SCRB | Software Change Review Board |
| SCST | Submarine Combat System Trainers (21a Series) |
| SCTR | Sector |
| SDB | Serial Data Bus |
| SDBL | Supportability Design Baseline |
| SDC | Shaft Driven Compressor |
| SDC | Signal Data Converter |
| SDC | Super Data Coder |
| SDD | Software Design Document |
| SDDD | Software Detailed Design Document |
| SDE | Software Development Environment |
| SDEX | Standard Executive |
| SDF | Software Development File |
| SDGW | Structural Design Gross Weight |
| SDIO | Strategic Defense Initiative Office |
| SDL | Software Development Library |
| SDLM | Scheduled Depot Level Maintenance |
| SDMS | Shipboard Data Multiplex System |
| SDP | Software Development Plan |
| SDR | Software Design Review |
| SDR | Software Discrepancy Report |
| SDR | System Design Review |
| SDRD | Supportability Design Requirements Document |
| SDRL | Supplier Data Requirement List |
| SDV | Swimmer Delivery Vehicle (special Warfare) |
| SE | Software Engineering |
| SE | Support Equipment |
| SE | System Engineering |
| SEA | NYMPHan/wlq-4 |
| SEAFARER | Pvs |
| SEAFIRE | Navy Shipborne Electro-optical Sensor & Laser Target Desig |
| SEAFOX | Special Warfare Craft Light |
| SEAMIS | Navsea Acquisition Management Information Systems |
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