| Acronym | Meaning |
 | SEARCHWATER | Radar |
| SEAS | Surveillance Environ Acoustic Supp |
| SEAWARS | Sea Water Actuated Release System (air) |
| SEB | Support Equipment Bulletin (tdc 63) |
| SEC | Secondary |
| SEC | Secure |
| SEC | Support Equipment Change (tdc 62) |
| SECAS | Ship Equipment Configuration Accounting System |
| SECNAV | Secretary Of The Navy |
| SECVOX | Secure Voice (comm) |
| SEE | Software Engineering Environment |
| SEI | Software Engineering Institute |
| SEL | Select |
| SEM | Standard Electronic Module |
| SEMATECH | A Consortium |
| SEMDP | Senior Executive Management Development Program |
| SEP | Software Enhancement Proposal |
| SEP | System Engineering Process |
| SEPG | Software Engineering Process Group |
| SEQ | Sequence |
| SERD | Support Equipment Recommendation Data |
| SERNO | Serial Number |
| SES | Surface Effect Ship |
| SEU | Sighting Electronics Unit |
| SEU | System Electronics Unit |
| SFGL | Name Of French Software Company |
| SGML | Standard Generalized Markup Language |
| SHA | System Hazard Analysis |
| SHIPALT | Ship Alteration |
| SHP | Shaft Horse Power |
| SHPL | Shp Left |
| SHPR | Shp Right |
| SHSC | Safety Hazard Severity Code |
| SIADS | Sensor Integration Display Sharing (an/sqq-89) |
| SIG | GNDsignal Ground |
| SIL | Silence |
| SIL | Silent |
| SIL | Simulation Integration Laboratory |
| SIM | Simulation Ship's Inertial Navigation System |
| SIM | Software Engineering Environment (see) Information Model |
| SIM | Subsystem Interface Unit |
| SIM | Simulate |
| SIMAS | Sonar In-situ Mode Assessment |
| SIMSYS | Simulation System (software) |
| SINCGARS | Single Channel Ground And Airborn Radio System |
| SIP | System Integration Plan |
| SIT | System Integration Test (software/hardware Integration) |
| SJAG | Software Engineering Environment (see) Joint Activities Group |
| SKIPPER | Weapon System |
| SL | Sea Level |
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